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Objective: The protecting influence of methanolic extract of seaweed (Lobophora variegata) on cognitive as well as biochemical indices in N-Nitrosodiethylamine (NDEA, a potent carcinogen) treated Drosophila melanogaster is evaluated. Methods: In this study, Flies are divided into four groups; group 1–(control), group 2-flies were treated with 0.01% NDEA in food medium, group 3–with 0.01% NDEA and 0.01% Lobophora variegata methanolic extract (LVME) and group 4-with 0.01% LVME alone. Results: Behavioural abnormalities (negative geotaxis, phototaxis, smell and taste chemotaxis, hygrotaxis and thermotaxis) were quantitatively deviated in NDEA treated flies compared to control but were tend to be normalized in LVME treated flies. The contents of protein carbonyl, thiobarbituric acid reactive substance (TBARS), protein thiol and lipid peroxides were noticeably augmented in NDEA treated flies than control flies and correspondingly tend to normalize in LVME treated groups. Further, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and reduced glutathione (GSH) were decreased in NDEA treated group and were significantly increased (p |
