Biogenic Synthesis of Rod Shaped ZnO Nanoparticles Using Red Paprika (Capsicum annuum L. var. grossum (L.) Sendt) and Their in Vitro Evaluation

Autor: Zaira Isabel González-Sánchez, Sekar Vijayakumar, Myeong-Hyeon Wang, Kandasamy Saravanakumar, Baskaralingam Vaseeharan, Mani Divya, Balasubramanian Malaikozhundan, Esteban F. Durán-Lara
Rok vydání: 2020
Předmět:
Zdroj: Journal of Cluster Science. 32:1129-1139
ISSN: 1572-8862
1040-7278
Popis: Metal oxide nanoparticles (NPs) have gained attention in biomedicine due to their broad spectrum of applications, such as targeted drug delivery, their use as antibacterial agents or in cancer treatments. In particular, zinc oxide nanoparticles (ZnO NPs) have become one of the most popular metal oxide NPs in biomedical applications. The present study describes for the first time the biogenic synthesis of rod shaped ZnO NPs using C. annuum L. var. grossum (L.) Sendt) extract as a capping agent. The purified C. annum-based zinc oxide nanorods (Ca-ZnO NRs) were characterized by different physico-chemical techniques. UV–vis spectroscopy depicted the absorbance peak at 372 nm. The size of nanorods ranges between 70 and 80 nm as revealed by FE-TEM micrographs and the mean size was 72 nm. Ca-ZnO NRs exhibited antibacterial activity in a dose-dependent manner and a greater activity was observed against S. enterica. Ca-ZnO NRs have shown antioxidant activity (91%) at 100 μg ml−1 when compared to the standard (ascorbic acid) (98%). A significant inhibition of bovine serum albumin (BSA) protein denaturation evidenced their anti-inflammatory property. Further, Ca-ZnO NRs showed hemolysis of red blood cells (RBC) (~ 3%) (up to 3 μg ml−1) which is much lesser than permissible limit.
Databáze: OpenAIRE
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