The effects on thermoregulatory mechanisms produced by intracerebroventricular injections of histamine in the sheep
| Autor: | C.A. Smith, Ann Silver, John Bligh |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Physiology Chemistry digestive oral and skin physiology Methysergide Thermoregulation Inhibitory postsynaptic potential Biochemistry Peripheral Atropine chemistry.chemical_compound Endocrinology Hypothalamus Internal medicine medicine Excitatory postsynaptic potential General Agricultural and Biological Sciences hormones hormone substitutes and hormone antagonists Histamine Developmental Biology medicine.drug |
| Zdroj: | Journal of Thermal Biology. 5:41-51 |
| ISSN: | 0306-4565 |
| Popis: | 1. 1. The effects on thermoregulatory mechanisms of intracerebroventricular (ICV) injections of histamine at doses between 5and 1000 nmol.kg −1 have been studied in sheep at different ambient temperatures ( T a ). 2. 2. In doses up to 800 nmol.kg −1 ICV histamine increased respiratory frequency (RF) and peripheral vasomotor tone (PVMT) at T a 20°C. These two effects were prevented by, respectively, methysergide and atropine. 3. 3. At higher dose levels or at higher T a ICV histamine decreased RF and PVMT. 4. 4. ICV histamie only rarely increased heat production. 5. 5. It is suggested that histamine may be excitatory at some synapses and inhibitory at others in the hypothalamic thermoregulatory centre. |
| Databáze: | OpenAIRE |
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