Geometrical structures, thermal properties and spectroscopic studies of Schiff base complexes: Correlation between ionic radius of metal complexes and DNA binding
| Autor: | Adel Z. El-Sonbati, H.R. Eissa, Sh.M. Morgan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Inorganic chemistry
010402 general chemistry 01 natural sciences Metal chemistry.chemical_compound symbols.namesake Transition metal Bathochromic shift Materials Chemistry Physical and Theoretical Chemistry Spectroscopy Schiff base Ionic radius 010405 organic chemistry Condensed Matter Physics Binding constant Atomic and Molecular Physics and Optics 0104 chemical sciences Electronic Optical and Magnetic Materials Gibbs free energy Crystallography chemistry visual_art visual_art.visual_art_medium Proton NMR symbols |
| Zdroj: | Journal of Molecular Liquids. 240:752-776 |
| ISSN: | 0167-7322 |
| DOI: | 10.1016/j.molliq.2017.05.114 |
| Popis: | A novel series of transition metal complexes of Cu(II), Co(II), Ni(II), Mn(II) and Cd(II) were prepared from Schiff base derived from 4-aminoantipyrine and quinoline-2-carbaldehyde to give 4-((quinolin-2-yl)methyleneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one (QMP). The structural features were derived from elemental analysis, mass spectroscopy, X-ray, IR, 1H NMR, electronic spectra, molar conductance magnetic susceptibility and thermogravimetric studies. On the basis of the studies the coordination sites were proven to be through oxygen of the ring C O and nitrogen of the azomethine (HC N) group. The thermodynamic parameters were calculated using Coats–Redfern and Horowitz–Metzger methods. From the values of the thermal activation energy of decomposition (Ea) of Schiff base (QMP) and its metal complexes (1–5), it was found that the Ea value for the complex (3) is higher compared to the other complexes. The Gibbs free energy of decomposition (ΔG⁎) for Schiff base (QMP) and its metal complexes is positive value which indicates that the processes are non-spontaneous. The interaction between Schiff base (QMP) and its metal complexes and calf thymus DNA shows hypochromism effect coupled with obvious bathochromic shift. From the values of binding constant (Kb) we noted that the highest value of Kb is belong complex (3) and these indicated that the Ni(II) is highly binding with CT-DNA and these due to the lower ionic radius. Furthermore, quantum chemical parameters of Schiff base and its complexes were calculated and discussed. The antimicrobial activity of Schiff base (QMP) and its M(II) complexes were studied and compared with the standard antibacterial and antifungal drugs. |
| Databáze: | OpenAIRE |
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