Methacrylic acid-co-butylmethacrylate copolymers: design, characterization and evaluation as encapsulating material for colon targeted formulations
| Autor: | Dipak K. Majumdar, Satish Manchanda, Amit Arya, Dharam Pal Pathak |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Materials science
Polymers and Plastics General Chemical Engineering 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Polymer chemistry Materials Chemistry medicine Microparticle chemistry.chemical_classification technology industry and agriculture General Chemistry Polymer Monomer Methacrylic acid chemistry Chemical engineering Polymerization 030220 oncology & carcinogenesis Radical initiator Aceclofenac 030211 gastroenterology & hepatology Swelling medicine.symptom medicine.drug |
| Zdroj: | Designed Monomers and Polymers. 19:34-46 |
| ISSN: | 1568-5551 |
| DOI: | 10.1080/15685551.2015.1092011 |
| Popis: | Hydrophilic monomer methacrylic acid was copolymerized with hydrophobic monomer butylmethacrylate in different molar ratio, using AIBNfree radical initiator. Successful polymerization was confirmed by FTIR and 1H NMR, while DSC and XRD revealed the amorphous nature of the polymers. Copolymers were highly hemocompatible. The polymers showed pH-dependent swelling and erosion which increased with increase in pH. As the amount of methacrylic acid increased, the swelling and erosion also increased. Polymers were used for the microencapsulation of a model anti-inflammatory drug, aceclofenac by an oil-in-oil solvent evaporation method. Microparticles were characterized using FTIR, XRD, DSC, and SEM analysis. The negatively charged particles were almost spherical in shape. The drug release was best explained by zero-order kinetics with anomalous release mechanism. Less than 1% of drug was released at pH 1.2 while the bulk of the drug load was released at pH 6.8 or above, confirming the colon-targeting nat... |
| Databáze: | OpenAIRE |
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