| Popis: |
The favorable influence of sodium thiosulphate on the toxic effects produced by the administration of arsenical, mercurial or lead compounds has been definitely shown by Ravaut, 1 McBride and Dennie, 2 Hoffmann and Schreus 3 and others. 4 Their reports deal especially with the after-effects of the arsphenamins in regard to arsenical rash, dermatitis, jaundice and intoxications. Clinical and pathologic findings demonstrate that intoxication with arsenic, mercury, lead and other metallic compounds produces irritation of the skin, liver and kidneys. If this irritation continues over a long period of time, degenerative changes will result. The fact that the skin is usually first affected in postarsphenamin reactions, and secondarily the liver or kidneys, may be due to a disturbed physiologic action of the skin. The function of the skin and its relationship to the autonomic nervous system has been discussed in the interesting studies by Mueller. 5 The different stages from mild |
