Synthesis approach and biological activity evaluation of a series of 1,3,2-oxazaphosphole-2-oxides against inflammation and nociception
| Autor: | Eman Sabry, Abeer A. Shaddy, Wafaa M. Abdou |
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| Rok vydání: | 2018 |
| Předmět: |
Cyclophosphamide
010405 organic chemistry Chemistry Substrate (chemistry) Biological activity Inflammation General Chemistry 010402 general chemistry Ibuprofen 01 natural sciences Combinatorial chemistry 0104 chemical sciences Nociception In vivo Lipophilicity medicine medicine.symptom medicine.drug |
| Zdroj: | Monatshefte für Chemie - Chemical Monthly. 150:283-294 |
| ISSN: | 1434-4475 0026-9247 |
| DOI: | 10.1007/s00706-018-2312-x |
| Popis: | In the present work, we synthesized a series of substituted benzoxazaphosphole-2-oxides in high yields (68–84%). The approach involved the preparation of oxazaphospholo-2-oxide monochloride, which is the key substrate, followed by its treatment with amino-, hydroxyl-, and thiolocompounds under mild conditions to afford the corresponding cyclophosphamide, cyclophosphamidate, and cyclophosphathioamidate groups as target products. Lipophilicity prediction and in vivo antinociceptive and antiinflammatory properties of new molecules were determined. Out of 14 tested compounds, the most hydrophobic compounds were found to be also of the highest antinociceptive and the antiinflammatory effects compared with reference drugs ibuprofen and indomethacin. The pharmacological results also showed that three candidates from the cyclophosphamide group are more active as antiinflammatory agents than the reference drug at all the successive time intervals. |
| Databáze: | OpenAIRE |
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