Lipid Peroxidation and Antioxidant System Activity Changes of Rat Blood and Cardiac Muscle Cells Under Chronic Stress
| Autor: | Nana Koshoridze, Zurab Kuchukashvili, Natalia Dachanidze, George Burjanadze, Ketevan Menabde |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Antioxidant biology Thiobarbituric acid medicine.medical_treatment Cardiac muscle Nitric oxide Superoxide dismutase Lipid peroxidation chemistry.chemical_compound Endocrinology medicine.anatomical_structure Biochemistry chemistry Catalase Internal medicine medicine biology.protein Chronic stress |
| Zdroj: | International Journal of Biochemistry and Biophysics. 1:16-21 |
| ISSN: | 2331-9933 2331-9925 |
| DOI: | 10.13189/ijbb.2013.010103 |
| Popis: | We studied the functionality of the antioxidant system in laboratory rat cardiac muscle cells and blood under psycho-emotional stress. It was found that 40-day isolation and violation of diurnal cycle among the animals were accompanied by the intensification of lipid per oxidation process shown by a rise in the quantity of one of the primary and final products of this process - diene conjugates and thiobarbituric acid active compounds, including malonedialdehydes and marked with a reduced activity of antioxidant system enzymes, such as catalase and superoxide dismutase activity. Based on the results, we pro-posed that psychological stress is one of the factors contributing to the development of various cardiac diseases. |
| Databáze: | OpenAIRE |
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