A Voltammetric Sensor Based on a 3,4,9,10-Perylenetetracarboxylic Acid Composite for the Recognition and Determination of Tyrosine Enantiomers

Autor: D. I. Dubrovskii, V. M. Kornilov, R. A. Zil’berg, Yu. A. Yarkaeva, Valery N. Maistrenko
Rok vydání: 2020
Předmět:
Zdroj: Journal of Analytical Chemistry. 75:1537-1545
ISSN: 1608-3199
1061-9348
DOI: 10.1134/s1061934820110143
Popis: An enantioselective voltammetric sensor based on a glassy carbon electrode modified with a composite of a polyelectrolyte complex of chitosan, Carboblack C graphitized thermal carbon black, and 3,4,9,10-perylenetetracarboxylic acid is developed for the recognition and determination of tyrosine enantiomers. The enantioselectivity of the sensor is due to the formation of self-organizing chiral nanoclusters of 3,4,9,10-perylenetetracarboxylic acid. The electrochemical and analytical characteristics of the sensor are studied. The proposed sensor is used to recognize and determine L- and D-enantiomers of tyrosine in samples of urine and human blood plasma, as well as in a mixture. To increase the probability of the recognition of tyrosine enantiomers in determining them in a mixture, the chemometric method of projection to latent structures is used. It is shown that the proposed sensor ensures the determination of the ratio of L- and D-enantiomers of tyrosine in a mixture with a high probability and a relative error of less than 8%.
Databáze: OpenAIRE
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