Justification of the possible directions of pathogenetic therapy of a new coronavirus infection
| Autor: | YuV Lobzin, AV Fomichev, AE Sosyukin, VL Rejnyuk, B. S. Litvincev, EB Shustov, MB Ivanov |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Biology medicine.disease medicine.disease_cause Virology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine 030212 general & internal medicine Endothelial dysfunction Oxidative stress Coronavirus |
| Zdroj: | Medicine of Extreme Situations. |
| Popis: | The article analyzes the links of pathogenesis of a new coronavirus infection that lead to severe clinical manifestations of the disease – acute respiratory distress syndrome, multiple organ failure and endotoxicosis. The sequence of development of the infectious process from the moment the virus enters the body from the external environment to the damage of the alveolar-capillary barrier and the development of acute respiratory distress syndrome is presented. Factors of initiation of pathological processes leading to the development of acute respiratory distress syndrome are described, among which special attention is paid to oxidative stress, hyperreactivity of the immune system, endothelial dysfunction and cytotoxic action of the virus. Possible pharmacotherapeutic directions of COVID-19 treatment are discussed, taking into account different pathogenesis links. Flowcharts for the sequence of events during COVID-19 infection have been developed. |
| Databáze: | OpenAIRE |
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