Piericidins, Novel Quorum-Sensing Inhibitors against Chromobacterium violaceum CV026, from Streptomyces sp. TOHO-Y209 and TOHO-O348

Autor:	Ryo Ishihara, Tomoe Yamanaka, Yojiro Anzai, Kazuhiro Ooka, Atsushi Fukumoto, Fumio Kato, Kanako Shimada
Rok vydání:	2013
Předmět:	Quorum sensing Biochemistry biology Gene expression Biofilm Bioluminescence Swarming motility biology.organism_classification Streptomyces Chromobacterium violaceum Virulence factor Microbiology
Zdroj:	Open Journal of Medicinal Chemistry. :93-99
ISSN:	2164-313X 2164-3121
DOI:	10.4236/ojmc.2013.34012
Popis:	Piericidin A1, 3’-rhamnopiericidin A1, and a novel compound piericidin E, a new quorum-sensing (QS) inhibitor against Chromobacterium violaceum CV026, were isolated from the culture broth of Streptomyces sp. QS is well known as a microbial signaling system and controls certain types of gene expression resulting in bioluminescence, biofilm formation, swarming motility, antibiotic biosynthesis, and virulence factor production. C. violaceum CV026 is commonly used to determine qualitative and quantitative QS activity. The structures of piericidin derivatives were characterized, and their QS activities were determined.
Databáze:	OpenAIRE
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