| Autor: |
Robert A. Kesterson, Sandra A. Kerner, Keiichi Ozono, J. Wesley Pike, Teruki Sone |
| Rok vydání: |
1993 |
| Předmět: |
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| DOI: |
10.1016/b978-0-08-092500-4.50011-5 |
| Popis: |
Publisher Summary This chapter focuses on the use of the osteocalcin gene as a molecular model for tissue-specific expression and dihydroxyvitamin D 3 regulation. The studies discussed in the chapter describe recent advances in the understanding of the molecular mechanisms by which the osteoblast specific bone protein osteocalcin is regulated at the genomic level. The gene is controlled at the basal level by a series of cis -acting elements that function together with their cognate transactivators at appropriate times during osteoblast maturation. Transgenic studies suggest the presence of tissue-specific activators. The gene is modulated by a series of steroid hormones that include 1, 25(OH) 2 D 3 . The action of this hormone is mediated by the vitamin D receptor (VDR). Thus, it appears that the VDR requires a non-VDR protein for cooperative interaction with specific DNA. Current evidence suggests that the dimerization partner may be another member of the steroid receptor superfamily, namely the retinoid X receptors subfamily. This increase in complexity may well extend the diversity of response generated by the vitamin D hormone and its receptor protein. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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