Metabolic polymorphisms and the micronucleus frequency in buccal epithelium of adolescents living in an urban environment

Autor:	Patricia Sierra, Víctor Dávila, Andrea Arrieta, Lucía Valencia, Iris Abad, Regina Montero, Rafael Camacho, Yayoi X. Segura, Raquel Acosta Fuentes, Luis Serrano
Rok vydání:	2003
Předmět:	Genetics Epidemiology Health Toxicology and Mutagenesis Binucleated cells Pharynx Physiology Buccal administration Cheek Biology Epithelium stomatognathic diseases medicine.anatomical_structure stomatognathic system Micronucleus test medicine Micronucleus Body mass index Genetics (clinical)
Zdroj:	Environmental and Molecular Mutagenesis. 42:216-222
ISSN:	0893-6692
DOI:	10.1002/em.10186
Popis:	Micronuclei and other biomarkers were evaluated in oral cells from 11- to 16-year-old girls living in a foster home in the central area of Mexico City. Variables analyzed for possible association with these biomarkers include smoking habits, body mass index, metabolic polymorphisms for NAT1 and GSTM1 and whether the cells were obtained from the cheek or pharynx. The results indicated that individuals having the NAT1*10 homozygous genotype showed a significant increase in chromatin buds and binucleated cells. When the damage in the cheek was compared with damage in the pharynx, a significant increase in micronuclei and binucleated cells was found for the latter tissue in all the individuals analyzed.
Databáze:	OpenAIRE
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