The association between detection of Mycobacterium avium subsp. paratuberculosis DNA in feces and histopathological classification
| Autor: | Satoshi Fujiyoshi, Azusa Yagi, Yukiko Taniguchi, Shin-Ichi Sakakibara, Masatoshi Fujihara |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
General Veterinary biology 040301 veterinary sciences Paratuberculosis 04 agricultural and veterinary sciences Disease biology.organism_classification medicine.disease Virology 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound Real-time polymerase chain reaction chemistry Mycobacterium avium subsp. paratuberculosis medicine Chronic infectious disease DNA Feces 030304 developmental biology Mycobacterium |
| Zdroj: | Journal of Veterinary Medical Science. 82:541-545 |
| ISSN: | 1347-7439 0916-7250 |
| DOI: | 10.1292/jvms.18-0724 |
| Popis: | Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of Johne's disease (JD), a chronic infectious disease that causes intractable diarrhea in ruminants. To control the occurrence of JD in cattle, a national surveillance is conducted in Japan. Since 2013, real-time quantitative PCR has been used for definite diagnosis. In this study, we compared the amount of fecal MAP DNA with histopathological classification of ileocecal lesions. Multinomial logistic regression models enabled us to predict the probability of finding the histopathological classification from the amount of fecal MAP DNA. These results suggest that shedding level of MAP DNA could act as an indicator of JD progression. |
| Databáze: | OpenAIRE |
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