| Autor: |
B L Fehr, S. K. Woelfel, David R. Cook, Rudd Gd, Barbara W. Brandom |
| Rok vydání: |
1984 |
| Předmět: |
|
| Zdroj: |
Anesthesia & Analgesia. 63:309 |
| ISSN: |
0003-2999 |
| DOI: |
10.1213/00000539-198403000-00005 |
| Popis: |
The neuromuscular effects of atracurium were studied in 25 infants anesthetized with 1.0% end-tidal halothane and N2O-O2. Neuromuscular blockade was monitored by recording the electromyographic activity of the adductor pollicis muscle resulting from supramaximal stimulation of the ulnar nerve at 2 Hz for 2 sec at 10-sec intervals. To estimate dose-response relationships, three groups of five infants received 60, 80, and 100 micrograms/kg atracurium, respectively; another ten infants received 300 micrograms/kg (2 X ED95). The neuromuscular block produced by 60 micrograms/kg was 27% +/- 10.9 (SEM), by 80 micrograms/kg was 34% +/- 8.0 and from 100 micrograms/kg was 70% +/- 8.3. The ED50 and ED95 (estimated from linear regression plots of log dose vs probit of effect) were 85 micrograms/kg and 150 micrograms/kg, respectively. Neuromuscular blockade lasted 23 +/- 1.6 min at 1 X ED95 and 32.5 +/- 5.2 min at 2 X ED95. Changes in heart rate and mean arterial pressure were clinically insignificant. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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