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Background: Although motor limitations are not currently considered clinical manifestations of autism spectrum disorder (ASD), they should not be ignored because of their high incidence and considerable influence on functional activity. Objective: This study aimed to investigate the relationship between autistic features, motor function, and quality of life (QoL) in children with ASD. Methods: Sixty children diagnosed with ASD from both sexes participated in this study. They were assessed for autistic features, motor skills, and QoL using the Childhood Autism Rating Scale, Peabody Developmental Motor Scale, and the Arabic version of the Pediatric Quality of Life generic core scale. Results: There was a significant negative correlation (p |