Implications of the Hemoglobin Glycation Index on the Diagnosis of Prediabetes and Diabetes
| Autor: | Michael R. Lewis, James M. Hempe, Philip Raskin, Vanita R. Aroda, Karen C. Johnson, Sun H. Kim, Sangeeta R. Kashyap, Jean Park, David C. Robbins, Cyrus Desouza, Neda Rasouli, William C. Knowler, Erin S. LeBlanc, Patricia R. Sheehan, Irwin G. Brodsky, Christine W. Lary, Emilia Liao, Myrlene A. Staten, Cyruse Desouza, Bess Dawson-Hughes, Richard E. Pratley, John P. Foreyt, Rowena J. Dolor, Ranee Chatterjee, Patrick M. O'Neil, Daniel S. Hsia, Lawrence S. Phillips, Clifford J. Rosen, Chhavi Chadha, Lisa M. Neff, Adline Ghazi, Anne L. Peters, Lisa Ceglia, Saul Malozowski, Anastassios G. Pittas |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases Endocrinology Diabetes and Metabolism Clinical Biochemistry 030209 endocrinology & metabolism Type 2 diabetes Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Glycation Diabetes mellitus Internal medicine medicine 030212 general & internal medicine Prediabetes business.industry Biochemistry (medical) nutritional and metabolic diseases medicine.disease Postprandial chemistry Cohort Hemoglobin Glycated hemoglobin business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 105:e130-e138 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Objective Fasting plasma glucose (FPG), 2-hour plasma glucose (2hPG) from a 75-g oral glucose tolerance test (OGTT) and glycated hemoglobin (HbA1c) can lead to different results when diagnosing prediabetes and diabetes. The Hemoglobin Glycation Index (HGI) quantifies the interindividual variation in glycation resulting in discrepancies between FPG and HbA1c. We used data from the Vitamin D and Type 2 Diabetes (D2d) study to calculate HGI, to identify HGI-associated variables, and to determine how HGI affects prediabetes and diabetes diagnosis. Measurements A linear regression equation [HbA1c (%) = 0.0164 × FPG (mg/dL) + 4.2] was derived using the screening cohort (n = 6829) and applied to calculate predicted HbA1c. This was subtracted from the observed HbA1c to determine HGI in the baseline cohort with 2hPG data (n = 3945). Baseline variables plus prediabetes and diabetes diagnosis by FPG, HbA1c, and 2hPG were compared among low, moderate, and high HGI subgroups. Results The proportion of women and Black/African American individuals increased from low to high HGI subgroups. Mean FPG decreased and mean HbA1c increased from low to high HGI subgroups, consistent with the HGI calculation; however, mean 2hPG was not significantly different among HGI subgroups. Conclusions High HGI was associated with Black race and female sex as reported previously. The observation that 2hPG was not different across HGI subgroups suggests that variation in postprandial glucose is not a significant source of population variation in HGI. Exclusive use of HbA1c for diagnosis will classify more Black individuals and women as having prediabetes compared with using FPG or 2hPG. |
| Databáze: | OpenAIRE |
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