Three distinct regions of allelic loss at 13q14, 13q21-22, and 13q33 in prostate cancer

Autor: Jin-Tang Dong, Henry F. Frierson, James C. Boyd, Leland W.K. Chung, Eija-Riitta Hyytinen
Rok vydání: 1999
Předmět:
Zdroj: Genes, Chromosomes and Cancer. 25:108-114
ISSN: 1098-2264
1045-2257
DOI: 10.1002/(sici)1098-2264(199906)25:2<108::aid-gcc6>3.0.co;2-y
Popis: Chromosome 13 is one of the most frequently altered chromosomes in cancer, including carcinoma of the prostate. Two known tumor suppressor genes, RB1 and BRCA2, map to chromosome 13; however, recent reports suggest that unknown genes on 13q are more likely to be involved in the development of prostate cancer. In order more fully to define the genetic changes on chromosome 13 in prostate neoplasms, we analyzed 27 polymorphic microsatellite markers spanning the q arm for loss of heterozygosity in 40 primary tumors and in metastases from 11 other patients who died of prostate cancer. Of the 40 primary tumors, 23 (58%) showed LOH for at least one marker. Three distinct regions at q14, q21-22, and q33, defined by markers D13S267 D13S153, D13S166 D13S1225, and D13S259 D13S274, showed the most frequent LOH, suggesting their involvement in the development of prostate cancer. For the 12 patients whose tumors showed LOH at these markers, the average age at diagnosis was 58 years, which was younger than that (63 years, P
Databáze: OpenAIRE
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