An efficient asymmetric catalytic hydrogenation of 4-aryl coumarins, preparation of a key intermediate in the synthesis of a class of endothelin receptor antagonists

Autor:	Susan Shilcrat, Michael A. McGuire, Edmund M. Sorenson
Rok vydání:	1999
Předmět:	chemistry.chemical_classification Stereochemistry Aryl Organic Chemistry chemistry.chemical_element Coumarin Biochemistry Combinatorial chemistry Rhodium Ruthenium Catalysis chemistry.chemical_compound chemistry Yield (chemistry) Drug Discovery Endothelin receptor Lactone
Zdroj:	Tetrahedron Letters. 40:3293-3296
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(99)00478-5
Popis:	The 4-aryl-3, 4-dihydrocoumarin1 is a critical intermediate in the synthesis of two endothelin receptor antagonists. Asymmetry is introduced by the chiral catalytic hydrogenation of2. Reduction occurs only if the lactone is open (3). A number of chiral ruthenium and rhodium organometallic species are evaluated as catalysts. The reaction is optimized to produce1 in high yield andee. Asymmetry is introduced in 4-aryl-3, 4-dihydrocoumarin by the chiral catalytic hydrogenation of a coumarin. Download : Download full-size image
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::33acb0e3fbabf6190ff8eca295796f85 https://doi.org/10.1016/s0040-4039(99)00478-5 Zobrazit plný text záznamu Full Text from ScienceDirect