Ruthenium-Catalyzed C(sp2)–H Bond Bisallylation with Imidazopyridines as Directing Groups
| Autor: | Xinju Zhu, Wannian Liu, Xin-Qi Hao, Hui Jiang, Mao-Ping Song, Shuang Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Imidazopyridine
Tandem 010405 organic chemistry Hydrogen bond Organic Chemistry chemistry.chemical_element Substrate (chemistry) 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis Ruthenium chemistry.chemical_compound chemistry Functional group Pharmacophore |
| Zdroj: | The Journal of Organic Chemistry. 85:15167-15182 |
| ISSN: | 1520-6904 0022-3263 |
| Popis: | A Ru(II)-catalyzed bisallylation of imidazopyridines with vinylcyclopropanes or vinyl cyclic carbonate has been successfully realized. Notably, pharmacophore imidazopyridine was utilized as an intrinsic directing group, which gave access to value-added bisallylated products in high yields via double tandem C-H and C-C/C-O activation. The current methodology was featured with broad substrate scope, good functional group compatibility, and operational simplicity. |
| Databáze: | OpenAIRE |
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