A multicomponent, facile and catalyst-free microwave-assisted protocol for the synthesis of pyrazolo-[3,4-b]-quinolines under green conditions
| Autor: | Mandlenkosi Robert Khumalo, Suresh Maddila, Sreekantha B. Jonnalagadda, Surya Narayana Maddila |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Reaction conditions
chemistry.chemical_classification General Chemical Engineering Aryl High selectivity 02 engineering and technology General Chemistry Aqueous ethanol 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Combinatorial chemistry Microwave assisted Aldehyde 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Dimedone 0210 nano-technology |
| Zdroj: | RSC Advances. 9:30768-30772 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c9ra04604f |
| Popis: | A facile, swift and ecofriendly microwave-assisted multi-component/one-pot protocol is designed for the synthesis of novel pyrazolo-[3,4-b]-quinolines at ambient temperature in aqueous ethanol as a reaction medium. The 18 novel pyrazolo-[3,4-b]-quinoline derivatives were synthesized by fusion of chosen aryl aldehyde, dimedone and 5-amino-3-methyl-1-phenylpyrazole in excellent yields (91–98%). All the molecular structures were confirmed by 1H-NMR, 15N-NMR, 13C-NMR, and HRMS data analysis. Operational simplicity, easy handling, one-step simple workup procedure, mild reaction conditions, short reaction time (≤10 min), high selectivity and no by-product formation are the striking features of the protocol. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|