99mTc-MDP accumulation mechanisms in bone: Basic study on the adsorption onto hydroxyapatite

Autor:	Hiromi Wakao, Hiroshi Yuda
Rok vydání:	1996
Předmět:	business.industry Methylene diphosphonate Calcium pyrophosphate chemistry.chemical_element Calcium Phosphate body regions chemistry.chemical_compound Adsorption chemistry parasitic diseases Urea Medicine Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) business Nuclear chemistry
Zdroj:	Oral Radiology. 12:27-32
ISSN:	1613-9674 0911-6028
DOI:	10.1007/bf02351579
Popis:	The accumulation mechanisms of technetium-99m methylene diphosphonate (99mTc-MDP) were investigated using hydroxyapatite powder and various phosphates. After reaction with99mTc-MDP, radioactivity was analyzed using a scintillation counter. The adsorption of99mTc-MDP onto hydroxyapatite occurred within 30 sec, and was not temperature dependent at 0–95°C. There was no change in the adsorption of99mTc-MDP onto hydroxyapatite in 5 or 50mM water-soluble organic compounds (glucose or urea). Anions had a greater effect on adsorption than cations. The only phosphate with adsorption equal to that of hydroxyapatite was calcium pyrophosphate. Adsorption onto calcium hydrogenphosphate was low at a pH of 6.0 in comparison with hydroxyapatite. These findings suggest that the adsorption of99mTc-MDP onto hydroxyapatite is influenced by the concentration of coexisting anions and by the chemical constitution of the phosphate components.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::33a73c4f7dc3c18cb35b2f1a353d7ae1 https://doi.org/10.1007/bf02351579 Zobrazit plný text záznamu Full text from SpringerLink