Fluorescent biosensor for the selective determination of dopamine by TGA-capped CdTe quantum dots in human plasma samples
| Autor: | Zeinab Pourghobadi, Pari Mirahmadpour, Hakimeh Zare |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
02 engineering and technology
010402 general chemistry 01 natural sciences Inorganic Chemistry chemistry.chemical_compound Thioglycolic acid Electrical and Electronic Engineering Physical and Theoretical Chemistry Spectroscopy chemistry.chemical_classification Detection limit Chromatography Biomolecule Organic Chemistry technology industry and agriculture 021001 nanoscience & nanotechnology Fluorescence Atomic and Molecular Physics and Optics Cadmium telluride photovoltaics 0104 chemical sciences Electronic Optical and Magnetic Materials Amino acid chemistry Quantum dot 0210 nano-technology Biosensor |
| Zdroj: | Optical Materials. 84:757-762 |
| ISSN: | 0925-3467 |
| Popis: | As a vital catecholamine neurotransmitter released by the brain in human central nervous system, dopamine (DA) plays an important role in a wide range of physiological functions and the mechanism of actions in human body, and its accurate detection is required in medicine. The present study reports a novel, simple and cost-effective nano-biosensor based on a thioglycolic acid (TGA)-capped cadmium telluride (CdTe) quantum dots (QDs) for the sensitive detection of DA in alkaline media. The assembled QDs-based biosensor showed a linear working range of 0.5–10 μM and a detection limit of 0.35 μM. The highest recovery of 97% was obtained by using the prepared biosensor for the detection of DA in human blood plasma samples. Additionally, the biosensor exhibited high selectivity toward DA without the interfering effects of biomolecules including some amino acids and chlorides. The concept of TGA-capped CdTe QDs will open up a new insight into the determination of DA in biological fluids where DA is at low levels. |
| Databáze: | OpenAIRE |
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