Galectin-1 as a novel effector molecule of cytotoxic cells (P1061)
| Autor: | Gustavo Amarante-Mendes, Tiago Machado, Narciso Vieira, Telma Zorn, Marcelo Dias-Baruffi, Maurício Rodrigues, Seamus Martin |
|---|---|
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 190:121.2-121.2 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.190.supp.121.2 |
| Popis: | The mechanism of cytotoxicity mediated by Natural Killer (NK) cells and Cytotoxic T Lymphocytes (CTL) is involved in the control of cancer progression, virus mediated diseases and many other intracellular related pathologies. These cells are particularly adapted to promote contact mediated cell death due to their ability to produce a special type of organelles, namely secretory lysosomes, aka cytotoxic granules. By proteomic analysis, we identified dozens of putative novel cytotoxic granule proteins in NK and CTL, as well as most of the already known granule constituents. Here we show that galectin-1, a protein previously described to have immunomodulatory activity, including regulation of apoptosis, is indeed present inside the cytotoxic granules. Moreover, galectin-1 deficient mice display an impaired in vivo cytotoxic activity against antigen-specific targets, suggesting that galectin-1 is a novel effector component of the cytotoxic cell machinery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|