Synthesis of di-amino-salicil and some of its derivatives

Autor:	W. Berends, A. K. J. Mulder, J. M. Waisvisz
Rok vydání:	1955
Předmět:	chemistry.chemical_compound Water soluble chemistry Derivative (finance) In vivo Organic chemistry General Chemistry Phenols In vitro
Zdroj:	Recueil des Travaux Chimiques des Pays-Bas. 74:1323-1342
ISSN:	0165-0513
DOI:	10.1002/recl.19550741103
Popis:	From the work of R. Kuhn et al. it appeared that brominated derivatives of salicil have a high anti-bacterial activity in vitro, but that in vivo they show only little activity as a result of serum-binding. Base-substituted phenols are usually bound by serum to a smaller extent. Therefore, an amino-substituted bromo-salicil was synthesized. A water soluble derivative of this compound was also prepared.
Databáze:	OpenAIRE
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