Associations of Alu I/D Polymorphism of the Angiotensin Converting Enzyme Gene and 4b/a Polymorphism of the Nitric Oxide Synthase Gene with Heart Rate Variability and Cardiovascular Hemodynamics in Rowers
| Autor: | A. S. Bobylev, A. A. Kylosov, A. A. Melnikov |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Supine position biology Physiology business.industry Population Angiotensin-converting enzyme 030204 cardiovascular system & hematology Nitric oxide synthase 03 medical and health sciences 0302 clinical medicine Endocrinology Physiology (medical) Internal medicine Genotype biology.protein Heart rate variability Medicine Allele business education Gene 030217 neurology & neurosurgery |
| Zdroj: | Human Physiology. 44:605-607 |
| ISSN: | 1608-3164 0362-1197 |
| DOI: | 10.1134/s0362119718050080 |
| Popis: | We studied the influence of the ACEAluI/D and NOS3 4b/a polymorphisms on the heart rate variability (HRV) and cardiovascular hemodynamics (CVH, by cardiac rheography) in rowers, including Candidates for Master of Sports (CMS, n = 6) and athletes with no rank (AWR, n = 16). It has been found that the VO2max (р < 0.001) and HRV (all indexes, p < 0.05) in the supine and standing positions were higher in the CMS athletes than in AWR athletes. The frequency of the I allele of the ACE genein the CMS group (58%) did not differ from the mean population value (n = 855, 48.4%) but was higher than in the AWR group (13%, p = 0.035), which was associated with increased HF regardless of VO2max (p = 0.029). The frequencies of genotypes of NOS3 4b/a did not differ between groups, but the 4a allele was associated with an increased VLF%. Thus, elevated HRV in trained athletes may be caused by genetic factors, among which the I allele of the ACE gene may play an important role. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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