Ring-opening of chiral N-(3,4-dihydro-4-oxoquinazolin-3-yl)-substituted aziridines (Q∗-substituted aziridines): access to Q∗-free chirons

Autor:	Tony M. Raynham, Andrew P. Ayscough, William Gattrell, Robert S. Atkinson
Rok vydání:	1998
Předmět:	Enantiopure drug Nucleophile Stereochemistry Group (periodic table) Chemistry Organic Chemistry Drug Discovery Ring (chemistry) Biochemistry
Zdroj:	Tetrahedron Letters. 39:497-500
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(97)10586-x
Popis:	The presence of the quinazolin-4(3H)-one ring (Q∗) in N-(Q∗)-aziridines facilitates ring-opening by nucleophiles: removal of the Q∗ group from enantiopure ring-opened products gives useful chirons.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::338874c054a512ff24213dca4828056e https://doi.org/10.1016/s0040-4039(97)10586-x Zobrazit plný text záznamu Full Text from ScienceDirect