Tough, Rapidly Swelling Thermoplastic Elastomer Hydrogels for Hemorrhage Control
| Autor: | Alice M. Savage, Tyler R. Long, Mark Dadmun, Joseph L. Lenhart, Randy A. Mrozek, Halie Martin, Erich D. Bain, Frederick L. Beyer |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Toughness Materials science Polymers and Plastics Organic Chemistry 02 engineering and technology Polymer 010402 general chemistry 021001 nanoscience & nanotechnology Elastomer 01 natural sciences 0104 chemical sciences Inorganic Chemistry chemistry Phase (matter) Amphiphile Self-healing hydrogels Materials Chemistry medicine Composite material Thermoplastic elastomer Swelling medicine.symptom 0210 nano-technology |
| Zdroj: | Macromolecules. 51:4705-4717 |
| ISSN: | 1520-5835 0024-9297 |
| DOI: | 10.1021/acs.macromol.8b00428 |
| Popis: | We present a novel elastomer with an amphiphilic triblock/graft architecture, allowing it to rapidly swell in water and form a tough hydrogel. The design was motivated by uncontrolled hemorrhage, responsible for 80–90% of potentially survivable deaths of US soldiers over the past 15 years. The polymer is 5.7 times as absorbent and 3 times as tough as a state of the art gauze-based hemostatic dressing. It swells to equilibrium within seconds in phosphate buffered saline due to a microphase-separated morphology featuring a continuous mobile ionic phase supported by hydrophobic glassy domains and rubbery linkages, as observed by transmission electron microscopy and small-angle neutron scattering. Thickness-dependent swelling is as much as an order of magnitude faster than many tough hydrogels in the literature, yet toughness is comparable as a function of water content. The polymer is combined with gauze to form a rapidly swelling, fiber-reinforced hydrogel composite with promising mechanical properties. |
| Databáze: | OpenAIRE |
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