SNPs of the PSMA6 gene: Investigation of possible association with myocardial infarction and type 2 diabetes mellitus

Autor: Ewa Ninio, Nikolajs Sjakste, Viviane Nicaud, Alun Evans, I. Poudziunas, Tatjana Sjakste, F. Cambien, Claire Perret, Caroline Morrison, M. Lazdins, Valdis Pirags
Rok vydání: 2007
Předmět:
Zdroj: Russian Journal of Genetics. 43:444-450
ISSN: 1608-3369
1022-7954
DOI: 10.1134/s102279540704014x
Popis: In our preceding studies, we have identified microsatellite polymorphisms inside the PSMA6 gene and in its 5′ upstream region. Following the observed associations of microsatellite polymorphisms with non-insulin dependent diabetes mellitus and Graves’ disease, we extended the evaluation of PSMA6 genetic variations to cardiovascular disorders and non-insulin dependent diabetes mellitus. New polymorphisms in the promoter region and exon 6 of the gene were identified by direct sequencing of the promoter region and all seven exons of the gene in 30 individuals of the European descent. Two SNPs at positions −110 and −8 from the translation start, in the promoter region and 5′ UTR, respectively, were analyzed. Neither polymorphism was associated with the risk of myocardial infarction. No significant association of the polymorphisms with plasma lipid levels or BMI was observed. A borderline association of both polymorphisms with diastolic blood pressure was observed in the control group. Genotype −8CG was significantly more frequent in type 2 diabetes patients, and haplotype C−110/G−8, compared to C−110/G−8 was associated with a higher risk of NIDDM.
Databáze: OpenAIRE
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