Response to Comment on: Chauhan et al. (2010) Impact of Common Variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the Risk of Type 2 Diabetes in 5,164 Indians. Diabetes;59:2068–2074
| Autor: | S. Prakash, Rubina Tabassum, Giriraj R. Chandak, Ganesh Chauhan, Chittaranjan S. Yajnik, Sreenivas Chavali, Seema Bhaskar, M.V. Kranthi Kumar, Saurabh Ghosh, Om Prakash Dwivedi, Smita R. Kulkarni, Nikhil Tandon, Dwaipayan Bharadwaj, Anubha Mahajan, Charles J. Spurgeon |
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| Rok vydání: | 2010 |
| Předmět: |
Genetics
medicine.medical_specialty education.field_of_study SLC30A8 biology business.industry Endocrinology Diabetes and Metabolism Population Genome-wide association study Type 2 diabetes Population stratification medicine.disease Internal Medicine biology.protein Medicine business Psychiatry education TCF7L2 CDKAL1 Genetic association |
| Zdroj: | Diabetes. 59:e16-e16 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/db10-0868 |
| Popis: | We read with interest the letter by Gupta and Ebrahim (1) complimenting our article (2) published recently in Diabetes . As mentioned rightly by the authors, there have not been many well-powered association studies on type 2 diabetes in the Indian population; hence this collaborative effort, even though as a replication of established genome-wide association study (GWAS) signals, is indeed exemplary. While thanking the authors for acknowledging our contribution, we believe that the issue raised by them of spurious association because of population stratification has limited scientific basis. The issue of population … |
| Databáze: | OpenAIRE |
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