| Autor: |
Ezequiel Borgia, Sebastián Andrés Muñoz, Eliana Lancioni, Pierina Sansinanea, Ricardo Russo, Mercedes García, Enrique R. Soriano, Eleonora Bresan, Carmen De Cunto, Diana Dubinsky, Alicia Eimon, María Cristina Basta, Analía Alvarez, Ana Beron, Maria Agustina D’Amico, Cecilia Pisoni, M. Cosatti, J.C. Barreira, Carolina Carrizo |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Reumatología Clínica (English Edition). 11:73-77 |
| ISSN: |
2173-5743 |
| DOI: |
10.1016/j.reumae.2014.03.015 |
| Popis: |
Objective To investigate the prevalence and associations with clinical manifestations of anti-P ribosomal antibodies in patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE). Methods Clinical and serological data of 30 patients with juvenile-onset SLE (age at onset younger than 16 years) were compared with data of 92 patients with adult-onset SLE. Symptoms occurring during the entire disease course were considered. Anti-P ribosomal antibodies were tested by ELISA. Results Anti-P ribosomal antibodies were found significantly more often in pediatric-onset SLE patients (26.7% vs 6.5%; OR=5.21 [95% CI=1.6–16.5], P =.003). Alopecia (OR=10.11, 95% CI=1.25–97) and skin rash (non-discoid) (OR=4.1, 95% CI=1.25–13.89) were significantly associated with anti-P ribosomal antibodies. Conclusion Anti-ribosomal P antibodies are more often found in patients with juvenile SLE. Alopecia and skin rash were the only clinical manifestations associated to anti-ribosomal P antibodies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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