Unit activity in an epileptic focus formed in the cat motor cortex with tetanus toxin

Autor:	M. B. Rekhtman, V. M. Okudzhava, G. N. Kryzhanovskii, I. A. Mzhaviya
Rok vydání:	1979
Předmět:	Membrane potential CATS Physiology Tetanus Chemistry Toxin General Neuroscience Depolarization Hyperpolarization (biology) medicine.disease medicine.disease_cause medicine.anatomical_structure Cerebral cortex medicine Neuroscience Motor cortex
Zdroj:	Neurophysiology. 10:425-431
ISSN:	1573-9007 0090-2977
DOI:	10.1007/bf01063222
Popis:	Single unit activity was recorded intracellularly in the zone of an epileptic focus produced by injection of tetanus toxin into the cerebral cortex of cats. Epileptic activity of all neurons tested correlated with cortical discharges between fits. A group of neurons with continuous spontaneous activity, in which a steady fall of membrane potential and cyclic changes in the frequency of the spike discharges were observed was distinguished. In these neurons paroxysmal depolarization changes of membrane potential were found in the discharges between fits, without subsequent hyperpolarization of the membrane. Hyperpolarization potentials after paroxysmal depolarization shifts could be observed in neurons of other groups. The role of neurons of the different groups in the formation of an "epileptic aggregate," the main generator of pathologically enhanced excitation, is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::336701b1eb828b1d6aead22f362d4a60 https://doi.org/10.1007/bf01063222 Zobrazit plný text záznamu Full text from SpringerLink