Complexes of myo-Inositol-Hexakisphosphate (IP6) with Zinc or Lanthanum for the Decorporation of Radiocesium
| Autor: | Tatsuto Kiwada, Miho Aoki, Akira Odani, Kazuma Ogawa, Sumi Kadono, Tadahisa Fukuda |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
021110 strategic
defence & security studies Biodistribution Radionuclide Gastrointestinal tract Radiochemistry 0211 other engineering and technologies chemistry.chemical_element 02 engineering and technology General Chemistry General Medicine Zinc In vitro 03 medical and health sciences 0302 clinical medicine Adsorption chemistry In vivo 030220 oncology & carcinogenesis Drug Discovery Lanthanum Nuclear chemistry |
| Zdroj: | CHEMICAL & PHARMACEUTICAL BULLETIN. 65:261-267 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.c16-00792 |
| Popis: | Radioactive nuclides leak into the surrounding environment after nuclear power plant disasters, such as the Chernobyl accident and the Fukushima Daiichi Nuclear Power Plant disaster. Cesium-137 (137Cs) (t1/2=30.1 year), a water-soluble radionuclide with a long physical half-life, contaminates aquatic ecosystems and food products. In humans, 137Cs concentrates in muscle tissue and has a long biological half-life, indicating it may be harmful. myo-Inositol-hexakisphosphate (IP6) is a compound found in grain, beans, and oil seeds. IP6 has the ability to form insoluble complexes with metals, including lanthanum (La) and zinc (Zn). We hypothesized that La-IP6 and Zn-IP6 may promote the elimination of 137Cs from the body through the adsorption of La-IP6 and Zn-IP6 to 137Cs in the gastrointestinal tract. Therefore, in this study, we evaluated the adsorptive capacity of La-IP6 and Zn-IP6 complexes with 137Cs in vitro and in vivo. La-IP6 and Zn-IP6 complexes were stable in acidic solution (pH 1.2) at 37°C. In vitro binding assays indicated that La-IP6 and Zn-IP6 complexes adsorbed 137Cs, with the adsorption capacity of Zn-IP6 to 137Cs greater than that of La-IP6. To evaluate the usefulness of La-IP6 and Zn-IP6 in vivo, La-IP6 or Zn-IP6 was administrated to mice after intravenous injection of 137Cs. However, the biodistribution of 137Cs in the La-IP6 treated group and the Zn-IP6 treated group was nearly identical to the non-treated control group, indicating that La-IP6 and Zn-IP6 were not effective at promoting the elimination of 137Cs in vivo. |
| Databáze: | OpenAIRE |
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