[99mTc]Tc-iPSMA SPECT brain imaging as a potential specific diagnosis of metastatic brain tumors and high-grade gliomas
| Autor: | Claudia G. Bautista-Wong, Bayron A. Sandoval-Bonilla, Jorge Iván González-Díaz, Rosa María Villanueva-Pérez, Bárbara Nettel-Rueda, Guillermina Ferro-Flores, Keren Contreras-Contreras, Clara Santos-Cuevas, Paola Vallejo-Armenta, Juan Soto-Andonaegui |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Reactive gliosis business.industry Brain tumor SPECT Brain medicine.disease 030218 nuclear medicine & medical imaging Vascular endothelium 03 medical and health sciences 0302 clinical medicine Gliosis Neuroimaging 030220 oncology & carcinogenesis Glioma medicine Molecular Medicine Immunohistochemistry Radiology Nuclear Medicine and imaging medicine.symptom business |
| Zdroj: | Nuclear Medicine and Biology. :1-8 |
| ISSN: | 0969-8051 |
| DOI: | 10.1016/j.nucmedbio.2021.02.003 |
| Popis: | Background PSMA (prostate-specific membrane antigen) protein is heavily expressed in the proliferating microvasculature of high-grade gliomas (HGG) and brain metastases (BM). This research aimed to assess [99mTc]Tc-iPSMA SPECT brain imaging as a potential specific diagnosis of HGG and BM by PSMA-targeting in their proliferating vasculature. Methods Forty-one patients, with suspected brain tumors, as detected by enhanced MRI scanning, were enrolled to undergo preoperative [99mTc]Tc-iPSMA SPECT brain imaging. Semiquantitative image analyses, to evaluate the maximum target-to-background ratio (TBRmax), were performed. All diagnoses were histopathologically confirmed. PSMA expression was evaluated by immunohistochemistry (IHC) in 11 brain tumor tissues. TBRmax values were correlated with IHC results and tumor WHO grade (HGG vs LGG). Results [99mTc]Tc-iPSMA images showed increased uptake in BM, HGG, and recurrent gliomas (TBRmax of 25.1 ± 7.1, 18.5 ± 9.0, 15.0 ± 9.9, respectively), and was negative in treatment-naive patients with LGG and reactive gliosis. PSMA was highly expressed in the vascular endothelium of grade IV gliomas and BM, while its expression was extremely low in LGG and completely absent in gliosis. By using 2.8 as a threshold value for TBRmax, the specificity, sensitivity, PPV, NPV and accuracy were 100%, 94%, 100%, 77% and 95%, respectively. Conclusions The results of this pilot study show that [99mTc]Tc-iPSMA SPECT brain imaging is a specific and potentially useful neuroimaging tool for assessing tumoral neovasculature formation in gliomas and brain metastases. |
| Databáze: | OpenAIRE |
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