Polymerase chain reaction and its use in obstetrics

Autor:	Phillip R. Bennett, Timothy Overton, Antony D. Lighten
Rok vydání:	1995
Předmět:	biology business.industry DNA polymerase Guanine Stereochemistry Obstetrics and Gynecology Uracil Thymine chemistry.chemical_compound chemistry Deoxyribose Pediatrics Perinatology and Child Health biology.protein Nucleic acid Medicine business DNA Cytosine
Zdroj:	Fetal and Maternal Medicine Review. 7:159-173
ISSN:	1469-5065 0965-5395
DOI:	10.1017/s0965539500001297
Popis:	Deoxyribonucleic acid (DNA) is composed of a deoxyribose backbone, the three position (3') of each deoxyribose being linked to the five position (5') of the next by a phosphodiester bond. At the two position each deoxyribose is linked to one of four nucleic acids; the purines adenine or guanine or the pyrimadines thymine or cytosine. Each DNA molecule is made up of two such strands in a double helix with the nucleic acid bases on the inside. The bases pair by hydrogen bonding, adenine (A) with thymine (T) and cytosine (C) with guanine (G). Deoxyribonucleic acid is replicated by separation of the two strands and synthesis by DNA polymerases of new complementary strands. With one notable exception, the reverse transcriptase produced by viruses, DNA polymerases always add new bases at the 3' end of the molecule. Ribonucleic acid (RNA) has a structure similar to that of DNA but is always single stranded. The backbone consists of ribose, and uracil is used in place of thymine.
Databáze:	OpenAIRE
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