REACTION OF SINGLET OXYGEN WITH CHOLESTEROL IN LIPOSOMAL MEMBRANES. EFFECT OF MEMBRANE FLUIDITY ON THE PHOTOOXIDATION OF CHOLESTEROL

Autor:	Kunihiko Suwa, Tokuji Kimura, A. Paul Schaap
Rok vydání:	1978
Předmět:	Liposome Autoxidation Singlet oxygen Cholesterol Phospholipid General Medicine Photochemistry Biochemistry chemistry.chemical_compound Membrane chemistry Yield (chemistry) Membrane fluidity lipids (amino acids peptides and proteins) Physical and Theoretical Chemistry
Zdroj:	Photochemistry and Photobiology. 28:469-472
ISSN:	1751-1097 0031-8655
DOI:	10.1111/j.1751-1097.1978.tb06951.x
Popis:	— The photosensitized oxygenation of cholesterol in liposomal membranes results in the formation of the characteristic singlet oxygen product, 3β-hydroxy-5α-cholest-6-ene-5-hydroperoxide. The yield of this product was found to be strongly temperature dependent with 6- to 7-fold increase above the transition temperature of the membrane using 1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine or 1.2-dimyristoyl-sn-glycero-3-phosphorylcholine. In contrast, the formation of the radical autoxidation products of cholesterol was not significantly enhanced in these systems by higher temperatures. We conclude from the results that the oxidation of cholesterol by singlet oxygen in the artificial membranes is affected by both membrane fluidity and amount of hematoporphyrin incorporated into the membrane. The ratio of cholesterol to phospholipid which affects the morphology of membranes is a crucial factor in determining the yield of the singlet oxygen product.
Databáze:	OpenAIRE
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