Cysteine-rich secretory protein 3 and β-microseminoprotein on prostate cancer needle biopsies do not have predictive value for subsequent prostatectomy outcome
| Autor: | Anna Dahlman, Tineke Wolters, Anders Bjartell, Geert J.L.H. van Leenders, Fritz H. Schröder, Monique J. Roobol, Kees J. Vissers, Agnes Marije Hoogland |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.diagnostic_test Prostatectomy business.industry Urology medicine.medical_treatment Odds ratio medicine.disease Confidence interval Prostate cancer medicine.anatomical_structure Prostate Predictive value of tests Biopsy medicine Immunohistochemistry business |
| Zdroj: | BJU International. 108:1356-1362 |
| ISSN: | 1464-4096 |
| Popis: | OBJECTIVES: • To investigate whether cysteine-rich secretory protein 3 (CRISP-3) and/or β-microseminoprotein (β-MSP) expression in diagnostic prostate needle biopsies have predictive value for prostate cancer (PC) on radical prostatecomy (RP). • To evaluate their potential clinical implementation in a preoperative setting. PATIENTS AND METHODS: • In total, 174 participants from the European Randomized Study of Screening for Prostate Cancer, Rotterdam section, treated by RP for PC were included in the present study. • CRISP-3 and β-MSP immunohistochemistry was performed on corresponding diagnostic needle biopsies. • Outcome was correlated with clinicopathological parameters (prostate-specific-antigen, PSA; number of positive biopsies; Gleason score, GS; pT-stage; surgical margins at RP) and significant PC at RP (pT3/4, or GS > 6, or tumour volume ≥0.5 mL) in the total cohort (n= 174) and in a subgroup with low-risk features at biopsy (PSA ≤ 10 ng/ml, cT ≤ 2, PSA density |
| Databáze: | OpenAIRE |
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