HLA-DR4 SUBTYPE AND -B ALLELES IN DQB1*0302-POSITIVE HAPLOTYPES ASSOCIATED WITH IDDM
| Autor: | H. REIJONEN, S. NEJENTSEV, J. TUOKKO, S. KOSKINEN, E. TUOMILEHTO-WOLF, H. K. AKERBLOM, J. ILONEN, THE CHILDHOOD DIABETES IN FINLAND S GROUP |
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| Rok vydání: | 1997 |
| Předmět: |
musculoskeletal diseases
Autoimmune disease Genetics 0303 health sciences endocrine system diseases Immunology Haplotype nutritional and metabolic diseases Immunogenetics Biology medicine.disease 03 medical and health sciences 0302 clinical medicine immune system diseases Polymorphism (computer science) Genetic linkage Diabetes mellitus medicine Allele skin and connective tissue diseases Allele frequency 030304 developmental biology 030215 immunology |
| Zdroj: | European Journal of Immunogenetics. 24:357-363 |
| ISSN: | 1365-2370 0960-7420 |
| Popis: | We determined the distribution of DR4 subtypes in 309 DQB1*0302-positive haplotypes found in insulin-dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4% vs. 55.7%, P = 0.003) and a decrease of DRB1*0404 allele (23.6% vs. 40.0%, P = 0.0064) was revealed. A further analysis of extended haplotypes demonstrated strong linkages between various B alleles and DRB1*04 subtypes. HLA-B39 was more frequent in DRB1*0404-DQB1*0302-positive IDDM haplotypes compared with control ones (37.0% vs. 14.3%, P = 0.049), suggesting an involvement of the region telomeric to HLA-DRB1 in the susceptibility to IDDM. |
| Databáze: | OpenAIRE |
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