Differential toxicity of amorphous silica nanoparticles toward phagocytic and epithelial cells

Autor:	Heather Herd, Hamidreza Ghandehari, Alexander Malugin
Rok vydání:	2011
Předmět:	Programmed cell death Materials science Nanoparticle Bioengineering Nanotechnology General Chemistry Condensed Matter Physics Atomic and Molecular Physics and Optics Cell biology Membrane Apoptosis Cell culture Nanotoxicology Modeling and Simulation Toxicity General Materials Science Intracellular
Zdroj:	Journal of Nanoparticle Research. 13:5381-5396
ISSN:	1572-896X 1388-0764
Popis:	The objective of this study was to evaluate the influence of size and surface functionality of amorphous silica nanoparticles (SNPs) on their interaction with cultured cells. The intracellular uptake, phagocytic activity, and possible mechanisms of toxicity induced by SNPs were studied on murine alveolar macrophages and two epithelial cancer cell lines. It was found that phagocytic cells are more susceptible to amorphous SNPs than epithelial cells. SNPs with functionalized surfaces were capable to induce the formation of apoptotic cells to a higher extent than plain particles. Plain SNPs induced plasma membrane damage in phagocytic cells to a higher extent and caused cell death in a shorter period of time than surface-functionalized SNPs. The prevalence of necrotic mode of cell death was observed after treatment with plain SNPs. In the range studied surface functionality played an important role in SNPs toxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::334b30903b40f243e89e6093bf76c2b0 https://doi.org/10.1007/s11051-011-0524-7 Zobrazit plný text záznamu Plný text ve formátu PDF