Phytochemical Composition and Evaluation of Anti-Inflammatory Activity in Glycosmis pentaphylla (Retz.)DC. - An Ethnobotanically Important Medicinal Plant
| Autor: | P M Radhamany, Vinitha S Babu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
biology
Traditional medicine medicine.drug_class Chemistry Glycosmis pentaphylla Inflammatory response Ethyl acetate food and beverages Context (language use) General Medicine biology.organism_classification Anti-inflammatory Lipoxygenase chemistry.chemical_compound Rutaceae medicine Phytochemical composition biology.protein |
| Zdroj: | Advances in Zoology and Botany. 8:109-115 |
| ISSN: | 2331-5091 2331-5083 |
| DOI: | 10.13189/azb.2020.080305 |
| Popis: | The present study was undertaken with an objective to investigate the phytochemical composition and in vitro anti-inflammatory potential in the leaves of Glycosmis pentaphylla (Retz.) DC, an ethno-medicinally important medicinal plant belonging to the Rutaceae family. Determination of secondary metabolites in any plant material is necessary as it helps to know about the major constituents present in them. Extractants like hexane, ethyl acetate, acetone, ethanol and distilled water were selected based on the polarity of the solvents used and was further evaluated for phytochemicals through qualitative and quantitative analysis based on standard procedures. Inflammation is a part of body's immune response and it is necessary to heal the tissue damage through an inflammatory response. As modern non-steroidal anti-inflammatory drugs can cause severe side effects like depression, gastric problems and so on, it is advisable to use plant derived products to treat inflammation. In this context, the potential of Glycosmis pentaphylla as an anti-inflammatory agent has been critically evaluated using in vitro cyclooxygenase and lipoxygenase inhibitory assays. The results revealed that major secondary metabolites evaluated were present in the ethanolic extract, indicating that ethanol can dissolve most of the phytoconstituents. Also, on quantification, it was found that the leaf ethanolic extract possessed alkaloids as a major constituent. As secondary metabolites can possess several pharmacological activities like anti-bacterial, anti-fungal, anti-tumour and so on, the potential of Glycosmis pentaphylla in elucidating anti-inflammatory effects was checked through in vitro anti-inflammatory assays. It was observed that, the leaf extract showed promising cycloxygenase and lipoxygenase inhibition indicating that, the extract can be used as an effective non-steroidal anti-inflammatory drug. From the phytochemical composition, it can be gleaned that, the anti-inflammatory activity might be due to the presence of alkaloids. Hence, this research work can aid the pharmaceuticals to isolate herbal anti-inflammatory drugs rich in alkaloids from Glycosmis pentaphylla. |
| Databáze: | OpenAIRE |
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