Moderated Posters session: pulmonary hypertension and other conditionsP516Echocardiographic findings predicting mortality in pulmonary arterial hypertension: a systematic review and meta-analysisP517Impairment of endothelial-mediated coronary flow reserve in patients with Anderson Fabry diseaseP518Comparative evaluation of various echocardiography-based methods for the estimation of pulmonary vascular resistance in pulmonary hypertensionP519Detection of early radiotherapy-induced changes in myocardial cyclic variation in breast cancer patients - an ultrasound tissue characterization studyP520Right ventricle adaptation changes resulting from endurance training in the group of junior cyclists - sex is an important determinantP521Impact of pulmonary hypertension on the impairment of right ventricular longitudinal function in patients with obstructive sleep apnea syndromeP522Improvement of echocardiographic (TTE) estimation of pulmonary vascular resistance (PVR) in comparison with right heart catheter measurementsP523Assessment of left ventricular function in breast cancer patients with adjuvant treatment (combined anthracyclines and trastuzumab): two years follow upP5243D regional right ventricular function in pulmonary hypertensionP525Simple echocardiographic parameters to assess right ventricular systolic function in patients with precapillary pulmonary hypertension: a comparison with cardiac magnetic resonance imaging

Autor: M L Handoko, N Duchateau, I Krstic, S Wahi, C Santoro, M Konopka, S Tuohinen, C Venner, L Spinelli, VJM Baggen, MMP Driessen, MC Post, AP Van Dijk, JW Roos-Hesselink, AE Van Den Bosch, JJM Takkenberg, GT Sieswerda, C A Giudice, D Castaldo, A Pisani, B Trimarco, O Huttin, D Mandry, D Voilliot, JF Chabot, PY Marie, Y Juilliere, A Chaouat, C Selton-Suty, T Skytta, V Virtanen, PL Kellokumpu-Lehtinen, P Raatikainen, K Burkhard-Jagodzinska, W Krol, R Zdanowicz, M Starczewski, K Aniol-Strzyzewska, A Jakubiak, D Sitkowski, M Dluzniewski, W Braksator, A Buonauro, ML Bocchino, R Esposito, A Canora, A Vaccaro, S Castaldo, A Sanduzzi Zamparelli, M Galderisi, A Chong, M Deljanin Ilic, S Vrbic, D Marinkovic, S Ilic, M Sermesant, P Gibelin, E Ferrari, P Moceri, MC Di Pasqua, OA Spruijt, FPT Oosterveer, JT Marcus, HJ Bogaard, A Vonk Noordegraaf
Rok vydání: 2015
Předmět:
Zdroj: European Heart Journal – Cardiovascular Imaging. 16:S67-S69
ISSN: 2047-2412
2047-2404
Popis: Purpose: Pulmonary hypertension (PH) is a rare and severe disease for which right ventricular (RV) remodelling and function are associated with survival. The unique anatomy and structure of the RV limit 2D analysis, and its regional function has not been studied yet. We show the contribution of regional 3D deformation analysis for the study of RV remodelling in patients with PH, as compared to healthy controls. Methods: 3D RV echocardiographic sequences were prospectively obtained from 32 patients with PH (57±21y, 15 male) and 10 healthy controls (38±13y, 6 male). Myocardial tracking was performed by semi-automatic Tomtec 4D RV-Function 2.0 software. Volumes and EF were directly obtained from the software. Output RV meshes were post-processed to extract local deformation (area strain) and radial/circumferential/longitudinal displacement. Data were temporally realigned to allow inter-subject pattern comparison. Spatial correspondences were obtained from the software, and allowed statistical computation in 8 standard zones of the RV. Results: 19 patients (59%) were NYHA class III-IV at baseline. Over a mean FU of 49±41days, 5 patients died from cardiopulmonary causes. The highest contraction was at the RV lateral and inferior levels. Regional motion and deformation and global volume patterns for patients was significantly affected at the RV anterior, lateral, inferior, and trabecular and inlet septum. The first 4 segments were significantly associated with NYHA class and survival. Global area strain >-15% was a significant predictor of death (HR 411e12 [140 – 1.2e27]). Conclusion: Our study confirms that the segments into which RV contraction predominates are also the determinants of symptoms and survival in PH patients. This is of high relevance to establish the prognosis of such patients.
Databáze: OpenAIRE
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