Evaluating the Antifungal Activity of α-Bisabolol in Association with NaCl on Fusarium oxysporum in Maize Grains

Autor: Josenildo Cândido De Oliveira, Juliana Moura Mendes Arrua, Igara Oliveira Lima, César A C de Medeiros, Ânderson De Vasconcelos Pinto, Gezaíldo S Silva, Fillipe de Oliveira Pereira
Rok vydání: 2021
Předmět:
Zdroj: Current Microbiology. 78:604-610
ISSN: 1432-0991
0343-8651
DOI: 10.1007/s00284-020-02313-8
Popis: Fusarium infections result in reduced maize grain (Zea mays L.) yields and notable impacts on human and animal health. Research involving natural products to control fungi in food is a promising alternative. Combinations of α-bisabolol (AB) and sodium chloride (NaCl) may suggest the use of lower effective concentrations of the drugs. This study aimed to evaluate the antifungal potential of AB associated with NaCl against Fusarium oxysporum strains isolated from maize. Minimum inhibitory concentrations (MICs) values of AB and NaCl were determined by microdilution, and an association study was performed (checkerboard). Effects on fungal mycelial growth (poisoned substrate technique) and a maize grain contamination model were analyzed. AB presented MIC values ranging from 128 and 1024 μg/mL; NaCl inhibited fungal growth at 16,384 μg/mL. The AB/NaCl association study revealed synergism by decreasing inhibitory concentrations by eight times. In corn kernels, AB and NaCl, whether isolated (at MIC) or in association (at sub-inhibitory concentrations), significantly inhibited in vitro mycelial growth (P
Databáze: OpenAIRE
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