Severe Clostridium difficile colitis as potential late complication associated with COVID-19

Autor:	P Calvo-Espino, J Páramo-Zunzunegui, J E Danés-Grases, I Ortega-Fernández, L Otazu-Canals, A Menchero-Sánchez, C Diego-Hernández, I Ariza-Ibarra
Rok vydání:	2020
Předmět:	medicine.medical_specialty Toxic megacolon Abdominal pain medicine.drug_class business.industry Antibiotics Outbreak General Medicine medicine.disease Clostridium Difficile Colitis Internal medicine Pandemic medicine Surgery Colitis medicine.symptom business Complication
Zdroj:	The Annals of The Royal College of Surgeons of England. 102:e176-e179
ISSN:	1478-7083 0035-8843
Popis:	Spain has been one of the most affected countries by the COVID-19 outbreak. After the high impact of the pandemic, a wide clinical spectrum of late complications associated with COVID-19 are being observed. We report a case of a severe Clostridium difficile colitis in a post-treatment and recovered COVID-19 patient. A 64-year-woman with a one-month hospital admission for severe bilateral pneumonia associated with COVID-19 and 10 days after discharge presented with diarrhoea and abdominal pain. Severe C. difficile-associated colitis is diagnosed according to clinical features and CT findings. An urgent pancolectomy was performed due to her bad response to conservative treatment. Later evolution slowly improved to recovery. C. difficile-associated colitis is one of the most common hospital-acquired infections. Significant patient-related risk factors for C. difficile infection are antibiotic exposure, older age, and hospitalisation. Initial therapeutic recommendations in our country included administration broad-spectrum antibiotics to all patients with bilateral pneumonia associated with SARS-CoV-2. These antibiotics are strongly associated with C. difficile infection. Our patient developed a serious complication of C. difficile due to the use of broad-spectrum antibiotics. The appearance of late digestive symptoms in patients diagnosed and treated for COVID-19 should alert clinicians to the possibility of C. difficile infection. The updated criteria for severe colitis and severe C. difficile infection should be considered to ensure an early effective treatment for the complication.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::332ce22729f6ef354fd2ef1072865c5d https://doi.org/10.1308/rcsann.2020.0166 Zobrazit plný text záznamu