Effect of ligands binding on the isotherm of hybridization of the DNA-chip

Autor:	Y. Sh. Mamasakhlisov, Sh. A. Tonoyan, H. L. Tsaturyan, Vladimir F. Morozov
Rok vydání:	2017
Předmět:	0301 basic medicine 030103 biophysics Chemistry Hybridization probe Intercalation (chemistry) General Physics and Astronomy 010402 general chemistry 01 natural sciences 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound Biophysics DNA microarray Selectivity DNA
Zdroj:	Journal of Contemporary Physics (Armenian Academy of Sciences). 52:180-188
ISSN:	1934-9378 1068-3372
Popis:	The factors are analyzed, which influence both the hybridization thermodynamics and the DNA/DNA-duplex stability. The non-competitive hybridization of the DNA as well as the competitive hybridization on the surface are investigated. It is shown that the binding to the intercalating ligands results to an increase in the selectivity and sensitivity of the DNA chips.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::33205febfe6d333d04a39952ef34f6b9 https://doi.org/10.3103/s106833721702013x Zobrazit plný text záznamu Full text from SpringerLink