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Using a within-subjects design, rats were trained to run on a radial maze with a procedure that involved two types of learning (pi ace and eue) and two memory functions (working and reference memory). After performance had stabilized, injections of saline, 4, 8, and 16 mg/kg of the competitive NMDA antagonist CPP (±)-3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid were administered in a Latin-square design. Choiee accuraey on both the place task and the cue task was significantly impaired by 8 and 16 mg/kg ofCPP, whereas running times were signifieantly slowed only with 16 mg/kg. This pattern of results is different from the selective impairment on the place task found following disruptive lesions of and kindling within the hippocampus. These findings suggest that care should be taken in attributing ehanges in behavior following injeetions of NMDA antagonists to selective effects on the hippocampus. |
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