The influence ofin vivo exposure to tributyltin on reactive oxygen formation in oyster toadfish macrophages
| Autor: | C. D. Rice, B.A. Weeks |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Oyster toadfish
biology Chemistry Health Toxicology and Mutagenesis Ionophore chemistry.chemical_element General Medicine Calcium Toxicology biology.organism_classification Pollution Molecular biology In vitro law.invention chemistry.chemical_compound In vivo law Toxicity Tributyltin Chemiluminescence Nuclear chemistry |
| Zdroj: | Archives of Environmental Contamination and Toxicology. 19:854-857 |
| ISSN: | 1432-0703 0090-4341 |
| Popis: | The influence ofin vivo tributyltin (TBT) exposure on macrophage activation was compared to previously reported responses resulting fromin vitro exposure. Oyster toadfish (Opsanus tau) were treated weekly for six weeks with either sham, vehicle, 0.250, 0.750, or 2.5 mg/kg TBT. Resident peritoneal macrophages were isolated and chemiluminescence (CL) stimulated by TBT (50 μg/L) and synergistic combinations of the tumor promoter myristate acetate (PMA) and calcium ionophore (A23187) was compared between treatment groups. Chemiluminescence was reduced in a dose-dependent manner in response to both PMA + A23187- and TBT (50 μg/L)-stimulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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