Lithium-induced modiphication of the physicochemical state of membrane proteins and lipids in human erythrocytes

Autor:	G. P. Zubritskaya, E. I. Slobozhanina
Rok vydání:	2021
Předmět:	Materials Chemistry
Zdroj:	Proceedings of the National Academy of Sciences of Belarus, Biological Series. 66:295-301
ISSN:	2524-230X 1029-8940
DOI:	10.29235/1029-8940-2021-66-3-295-301
Popis:	The effect of various concentrations of lithium sulfate on human erythrocytes in vitro has been studied. It has been shown that the effect of lithium salt in maximum pharmacological and toxic concentrations on cells leads to a modification of the physicochemical state of membrane-bound proteins and lipids. It was found that in human erythrocytes exposed to lithium ions, there is a decrease in the activity of membrane-bound acetylcholinesterase and methgemoglobin reductase, as well as a change in the microviscosity of the lipid bilayer of membranes. The results obtained can be used to create a cell test system for assessing the toxicity of lithium compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::330b991a839a114fd39cec60d58b40e9 https://doi.org/10.29235/1029-8940-2021-66-3-295-301 Zobrazit plný text záznamu