Efficient synthesis of 5-bromo-2,3-dimethoxy-6-methyl-1,4-benzoquinone: key intermediate for preparing Coenzyme Q
| Autor: | Xiao Hu, Yong-Fu Qiu, Yi-Yu Yan, Jin Wang, Bin Lu, Wan-Yue Luo |
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| Rok vydání: | 2019 |
| Předmět: |
biology
Chemistry General Chemical Engineering Halogenation 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Biochemistry Medicinal chemistry Redox Industrial and Manufacturing Engineering Cofactor 0104 chemical sciences 1 4-Benzoquinone chemistry.chemical_compound Reaction sequence Yield (chemistry) Coenzyme Q – cytochrome c reductase Materials Chemistry biology.protein 0210 nano-technology |
| Zdroj: | Chemical Papers. 73:2745-2748 |
| ISSN: | 1336-9075 2585-7290 |
| DOI: | 10.1007/s11696-019-00826-6 |
| Popis: | The title compound, a key intermediate for preparing Coenzyme Qn family, was prepared in an excellent yield by a reaction sequence starting from the commercially available 3,4,5-trimethoxytoluene 1 via bromination, methoxylation and oxidation reactions. An 80% overall yield was demonstrated on a multi-gram scale. |
| Databáze: | OpenAIRE |
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