Randomized Trial to Prevent Sensitization to Mite Allergens in Toddlers and Preschoolers by Allergen Reduction and EducationOne-Year Results
| Autor: | Johannes Forster, Stella Tsitoura, Katerina Nestoridou, Jurgis Bojarskas, Wilfried Karmaus, Joachim Kuehr, Hassan Arshad, Calin Botezan, Panayotis Botis |
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| Rok vydání: | 2002 |
| Předmět: |
Pediatrics
medicine.medical_specialty Allergy biology business.industry medicine.disease medicine.disease_cause biology.organism_classification respiratory tract diseases law.invention Atopy Allergen medicine.anatomical_structure Randomized controlled trial immune system diseases law Food allergy Pediatrics Perinatology and Child Health medicine Mite business Sensitization Asthma |
| Zdroj: | Archives of Pediatrics & Adolescent Medicine. 156:1021 |
| ISSN: | 1072-4710 |
| DOI: | 10.1001/archpedi.156.10.1021 |
| Popis: | Objective To evaluate the effectiveness of prevention measures against dust mite sensitization. Design European (England, Germany, Greece, Lithuania) multicenter prospective single-blind randomized control trial with a follow-up of 12 months. Participants Toddlers and preschoolers, with at least 1 parent with atopic symptoms and sensitization, who initially were not sensitized to mite allergens. Interventions A combination of education and a simple preventive measure (mattress encasement) to reduce mite allergen exposure. Setting Community-based study. Main Outcome Measures Sensitization to mite allergens (skin-prick test or specific immunoglobulin E). Results Of 636 children (mean age, 3.1 years) included in the study, 566 (89%) participated in the first-year follow-up. The incidence of sensitization to mite allergens was 10 (3%) of 330 in the intervention vs 20 (6.5%) of 306 in the control arm, including loss of follow-up (intention-to-treat principle). Allergic symptoms were more common in sensitized than in nonsensitized children and so was the prevalence of physician-diagnosed asthma, eczema, and food allergy. Conclusions This simple, harmless, and inexpensive measure can be used in toddlers and preschoolers of parents with atopic disorders to reduce sensitization to mite allergens. With regard to clinical manifestations of atopy, follow-up studies are needed to determine the effectiveness of the intervention. |
| Databáze: | OpenAIRE |
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