Physico-chemistry and cytotoxicity of ceramics

Autor:	P. Havlik, R. Bareille, I. Dion, F. Lefebvre, J.R. Monties, Ch. Baquey, Laurence Bordenave
Rok vydání:	1994
Předmět:	Neutral red Biomedical Engineering Biophysics Bioengineering Haemolysis Molecular biology Biomaterials chemistry.chemical_compound chemistry Cell culture visual_art visual_art.visual_art_medium Cytotoxic T cell MTT assay Viability assay Ceramic Cytotoxicity Nuclear chemistry
Zdroj:	Journal of Materials Science: Materials in Medicine. 5:18-24
ISSN:	1573-4838 0957-4530
DOI:	10.1007/bf00121148
Popis:	General cytotoxicity was assayed for ceramic (Al2O3, ZrO2/Y2O3, AIN, B4C, BN, SiC, Si3N4, TiB4, TiC, TiN) diamond and graphite powders, using 3T3 Balb/c permanent cell lines. Neutral red test was carried out in order to establish cell viability. Further investigations were undertaken on human differentiated cells (human umbilical venous endothelial cells): cell behaviour (MTT assay, total cell protein content) and differentiation (immunofluorescence) were studied. In both cases, no cytotoxic effect has been noticed. All the impurities contained at low concentration in these powders do not seem to present any effect. The correlation which has been previously observed between cytotoxicity-cell culture response and blood haemolysis for polymers has not been established here for ceramic powders. We conclude that all the ceramic powders tested here and therefore the corresponding bulk ceramics or ceramic coatings do not induce any cytotoxic effect.
Databáze:	OpenAIRE
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